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Neuron. 2004 May 27;42(4):522-4.

Selective dopamine filter of glutamate striatal afferents.

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  • 1Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030 USA.


Corticostriatal glutamate afferents and mesostriatal dopamine afferents commonly converge onto the same postsynaptic spines of medium projection neurons. The consequent synaptic triad provides an ideal configuration for dopamine modulation of glutamatergic transmission. In this issue of Neuron, Bamford et al. report that dopamine inhibits glutamate release in a selective manner by activating presynaptic D2 receptors.

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