Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Oncogene. 2004 May 24;23(24):4315-29.

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.

Author information

  • 1Department of Cell Biology and Cancer Center University of Massachusetts Medical School, Worcester, M 01655, USA. gary.stein@umassmed.edu

Abstract

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.

PMID:
15156188
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk