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Antimicrob Agents Chemother. 2004 Jun;48(6):2314-7.

Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.

Author information

  • 1Coley Pharmaceutical GmbH, Elisabeth-Selbert-Strasse 9, D-40764 Langenfeld, Germany. jvollmer@coleypharma.com

Abstract

To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.

PMID:
15155243
[PubMed - indexed for MEDLINE]
PMCID:
PMC415599
Free PMC Article
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