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Bioorg Med Chem Lett. 2004 Jun 21;14(12):3323-6.

Synthesis of analogues of a potent antitumor saponin OSW-1.

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  • 1Institute of Chemistry, University of Bialystok, al. Pilsudskiego 11/4, 15-443 Bialystok, Poland. morzycki@uwb.edu.pl

Abstract

A series of side chain analogues (5a-e), a 22-glycosylated isomer (10), and 16beta-O-l-arabinosyl (13a) or 16beta-O-d-xylosyl (13b) analogues of OSW-1 were synthesized. All analogues were found to be less cytotoxic against breast and endometrial cancer cell lines than the natural product.

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