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J Exp Med. 2004 May 17;199(10):1301-4.

Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target.

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  • 1Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.


Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)--the one EBV antigen that is expressed in all EBV-associated malignancies--has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV-related cancers.

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