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Arch Neurol. 2004 May;61(5):705-14.

Relation of plasma lipids to Alzheimer disease and vascular dementia.

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  • 1Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Abstract

BACKGROUND:

The relation between plasma lipid levels and Alzheimer disease (AD) and vascular dementia (VaD), and the impact of drugs to lower lipid levels remains unclear.

OBJECTIVE:

To investigate the relation between plasma lipid levels and the risk of AD and VaD and the impact of drugs to lower lipid levels on this relationship.

DESIGN AND SETTING:

Cross-sectional and prospective community-based cohort studies.

PARTICIPANTS:

Random sample of 4316 Medicare recipients, 65 years and older, residing in northern Manhattan, NY.

MAIN OUTCOME MEASURES:

Vascular dementia and AD according to standard criteria.

RESULTS:

Elevated levels of non-high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C) and decreased levels of HDL-C were weak risk factors for VaD in either cross-sectional or prospective analyses. Higher levels of total cholesterol were associated with a decreased risk of incident AD after adjustment for demographics, apolipoprotein E genotype, and cardiovascular risk factors. Treatment with drugs to lower lipid levels did not change the disease risk of either disorder.

CONCLUSIONS:

We found a weak relation between non-HDL-C, LDL-C, and HDL-C levels and the risk of VaD. Lipid levels and the use of agents to lower them do not seem to be associated with the risk of AD.

PMID:
15148148
[PubMed - indexed for MEDLINE]
PMCID:
PMC2696387
Free PMC Article
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