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J Soc Biol. 2004;198(1):22-9.

[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].

[Article in French]

Author information

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, Université L. Pasteur de Strasbourg, BP 10142, 67404 Illkirch, France.

Abstract

In agreement with previous data in the literature, our results indicate that serotonin, a monoamine neurotransmitter, can also regulate cell proliferation, cell movements and cell differentiation. We have recently shown that serotonin is required for embryonic heart development. Genetic ablation of the 5-HT2B receptor leads to partial embryonic and postnatal lethality with abnormal heart development. Similar molecular mechanisms seem to be involved in adult cardiomyocytes since mutant mice surviving to adulthood display a dilated cardiomyopathy. Furthermore this receptor appears to be involved in survival of cardiomyocytes. The 5-HT2B receptor is also implicated in systemic hypertension. Furthermore, mice with pharmacological or genetic ablation of 5-HT2B receptor are totally resistant to hypoxia-induced pulmonary hypertension, indicating that this receptor is regulating the pathologic vascular proliferation leading to this disease. Underlying mechanisms are still to be discovered.

PMID:
15146952
[PubMed - indexed for MEDLINE]
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