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Eur Arch Psychiatry Clin Neurosci. 2004 Apr;254(2):76-81.

Affective and schizoaffective mixed states.

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  • 1Department of Psychiatry and Psychotherapy, Martin-Luther University Halle-Wittenberg, 06097 Halle, Germany. andreas.marneros@medizin.uni-halle.de


Although both DSM-IV and ICD-10 define schizoaffective mixed states, they have not received much attention-neither in the clinical nor in research context. We present preliminary results of a prospective study of bipolar affective (n = 100) and bipolar schizoaffective (n = 177) patients. 25% of the bipolar affective and 32% of the bipolar schizoaffective patients had at least one (schizo)mixed episode during the illness course. Nevertheless, (schizo)mixed episodes were rare-only 5.6% of all episodes. There was a trend that patients with (schizo)mixed episodes were more often women and exhibited more disability (reflected by higher rates of disability payments). Nevertheless, these differences failed to reach significance. Overall, schizo-mixed episodes are as frequent as "pure" affective mixed episodes. They might be linked to a less favourable course. Nevertheless, while their diagnostic criteria are problematic, they are systematically underdiagnosed.

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