Curr Opin Cell Biol. 2004 Jun;16(3):279-84.

The ever-increasing complexities of the exon junction complex.

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Howard Hughes Medical Institute, Department of Biochemistry, MS009, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.

Abstract

Over the past decade many studies have revealed a complex web of interconnections between the numerous steps required for eukaryotic gene expression. One set of interconnections link nuclear pre-mRNA splicing and the subsequent metabolism of the spliced mRNAs. It is now apparent that the means of connection is a set of proteins, collectively called the exon junction complex, which are deposited as a consequence of splicing upstream of mRNA exon-exon junctions.

PMID:: 15145352; [PubMed - indexed for MEDLINE]

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5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly. [Genes Dev. 2002]
5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.
Reichert VL, Le Hir H, Jurica MS, Moore MJ. Genes Dev. 2002 Nov 1; 16(21):2778-91.
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