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1: J Comp Pathol. 2004 Jul;131(1):70-6.Click here to read Links

Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas.

Borzacchiello G, Paciello O, Papparella S.

Universita degli Studi di Napoli Federico II, Dipartimento di Patologia e Sanita Animale, Via F. Delpino, 1, Napoli 80137, Italy.

Cyclooxygenase-1 (COX-1) and cyclooxygenase -2 (COX-2) are known to play a role in the carcinogenesis of many human and animal primary epithelial tumours. However, expression of COX-1 and -2 has not been investigated in canine nasal epithelial carcinoma, a rare form of neoplasia. COX-1 immunolabelling was demonstrated in normal canine nasal mucosa and in a minority of neoplastic specimens. Cytoplasmic COX-2, however, was strongly expressed in the majority of canine nasal carcinomas. In addition, COX-2 expression was demonstrated in dysplastic epithelium and in a proportion of stromal cells. Co-expression of both enzyme isoforms was revealed by confocal laser scanning microscopy. The results indicate that COX-2 is overexpressed in a proportion of naturally occurring canine nasal carcinomas, suggesting its possible role in canine nasal tumorigenesis. Copyright 2004 Elsevier Ltd.

PMID: 15144801 [PubMed - indexed for MEDLINE]