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    Dtsch Med Wochenschr. 2004 May 14;129(20):1145-8.

    [Diabetes-associated autoimmune disease in children and juveniles: how important is early recognition?]

    [Article in German]

    Kordonouri O, Danne T.

    Klinik für Allgemeine Pädiatrie, Otto-Heubner-Centrum für Kinder- und Jugendmedizin, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum. olga.kordonouri@charite.de

    Coeliac disease (CD) and autoimmune thyreoiditis (AIT) are associated with type-1 diabetes. These diseases frequently occur without apparent clinical symptoms. Therefore, a serological screening by autoantibody testing is required for early detection. Identified by screening, the prevalence of CD and AIT is reported to be up to 10-fold higher in young patients with type-1 diabetes than in healthy children. Up to now, no uniform recommendations exist regarding a standardized screening procedure as well as the treatment of patients with clinically asymptomatic disorder and evidence of autoimmunity. A delay in the detection of associated diseases, however, may lead to clinical relevant, but otherwise preventable complications.

    PMID: 15143457 [PubMed - indexed for MEDLINE]

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