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News Physiol Sci. 2004 Jun;19:148-53.

Connexins pave the way for vascular communication.

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  • 1Institut für Physiologie, Universität Lübeck, 23538 Lübeck, Germany.


Coordinated behavior within arterioles is necessary for large resistance changes to occur and is reflected as a conduction of dilations/constrictions along arterioles. These responses arise from locally initiated hyper- or depolarizations that propagate via transmembrane channels formed by connexins (gap junctions). Mounting evidence indicates that gap-junctional communication contributes to the control of vascular tone.

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