News Physiol Sci. 2004 Jun;19:92-6.

How free fatty acids inhibit glucose utilization in human skeletal muscle.

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First Medical Department, Hanusch Hospital, A-1140 Vienna, Austria.

Abstract

Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.

PMID:: 15143200; [PubMed - indexed for MEDLINE]

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