Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 2004 May 3;491(2-3):207-8.

Drosophila model for in vivo pharmacological analgesia research.

Author information

  • 1The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St., M/C912, Chicago, IL 60612, USA. HManev@psych.uic.edu

Abstract

Fruit flies (Drosophila melanogaster) are typically used for genetic studies but they also could be employed for neuropharmacological research. Therefore, we designed an apparatus and developed methods to investigate how injecting antinociceptive drugs, i.e., a gamma-aminobutyric acid B receptor agonist, to adult flies affects their avoidance of noxious heat stimuli. We found a drug-induced dose-dependent increased threshold for heat avoidance and we propose Drosophila as an ethically acceptable animal model for in vivo pharmacological analgesia research.

Copyright 2004 Elsevier B.V.

PMID:
15140638
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk