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Surg Oncol Clin N Am. 2004 Apr;13(2):389-94.

Recent clinical trials summary.

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  • 1Department of Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.


The current standard of care for the treatment of anal cancer as demonstrated by all of the completed phase 3 clinical trials remains 5-FU and mitomycin C in combination with radiation therapy. The basic elements of the approach outlined by Nigro have not changed in the last 30 years. Future phase 3 trials will serve to further perfect this approach and outline the role of HPV and dysplasia in the development and progression of this disease.

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