Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2004 May 14;117(4):421-6.

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

Author information

  • 1College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA. da230@columbia.edu

Abstract

Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation. Modest alterations of this balance can result in profound effects. The gamut of phenotypes runs from protection against diabetes and predisposition to neoplasia, conferred by FoxO loss of function, to increased cellular survival and a marked catabolic response associated with gain of function.

PMID:
15137936
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk