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Neurosci Lett. 2004 May 6;361(1-3):168-71.

The many functions of nerve growth factor: multiple actions on nociceptors.

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  • 1Department of Neurobiology and Behavior, Stony Brook, NY 11794-5230, USA.


Nerve growth factor (NGF) initially interested neurobiologists because of its effects in the developing nervous system. It is now clear that NGF functions throughout the life of the animal with a wide repertoire of actions. In the sensory nervous system it primarily influences the structure and function of nociceptors. Here, we provide a brief review of these actions and raise the overriding biological questions of why these multiple actions occur and how they are carried out.

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