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Am J Cardiol. 2004 May 15;93(10):1312-3.

Usefulness of the third heart sound in predicting an elevated level of B-type natriuretic peptide.

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  • 1Department of Cardiology, University of California-San Francisco, M1180D, 505 Parnassus Avenue, San Francisco, CA 94143-0124, USA.


Third heart sounds were sought in 100 consecutive outpatients who had B-type natriuretic peptide (BNP) levels measured within 8 hours. Mean BNP levels were significantly higher in those with a third heart sound. The presence of a third heart sound was 41% sensitive and 97% specific for elevated BNP levels.

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