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Am J Surg. 2004 May;187(5):612-7.

Outcomes after resection of cholangiocellular carcinoma.

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  • 1Department of General, Thoracic, and Vascular Surgery, Virginia Mason Medical Center, 1100 Ninth Ave., P.O. Box 900, M/S C6-SUR, Seattle, WA 98111 USA.

Abstract

BACKGROUND:

Cholangiocellular carcinoma (CCC) is a rare primary liver malignancy that arises from intrahepatic bile duct canaliculi and presents as a liver mass. Our purpose is to report operative morbidity and mortality and to determine long-term survival after resection for CCC.

METHODS:

Retrospective review of 31 consecutive patients who underwent resection during a 20-year period.

RESULTS:

Thirty-day hospital mortality was 3%, and postoperative morbidity was 38%. Kaplan-Meier 5-year survival was 35%; mean survival was 37 months; absolute 5-year survival was 33%. Mean survival in stages I, II, IIIA, and IIIC were 57, 33, 26, and 14 months, respectively (P = 0.03 comparing I to >I). Recurrence occurred in 18 patients; 89% were in the liver. Carbohydrate antigen 19-9 >100 U/mL was found to be an indicator of poor prognosis (P = 0.009).

CONCLUSIONS:

Resection for CCC can be performed with acceptable morbidity and mortality rates and results in good survival and cure. Hepatic recurrence is common. Carbohydrate antigen 19-9 may be useful in determining prognosis.

PMID:
15135676
[PubMed - indexed for MEDLINE]
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