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    Brain Res Mol Brain Res. 2004 May 19;124(2):199-203.

    Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid.

    Francis JS, Dragunow M, During MJ.

    Source

    Department of Molecular Medicine and Pathology, University of Auckland School of Medicine, Auckland, New Zealand.

    Abstract

    ATF-3 is a member of the ATF superfamily of transcription factors and is strongly associated with episodes of cellular stress. We demonstrate an association between increases in ATF-3 protein and resistance to exitotoxic cell death in vivo. Intra-hippocampal injection of kainic acid elicited a robust increase in endogenous ATF-3 within kainate-resistant cells of the dentate gyrus, while overexpression of exogenous ATF-3 was found to protect vulnerable CA3 neurons from the same insult. These results suggest a positive contribution to neuronal survival in the context of stress-induced death, and support an anti-apoptotic role for ATF-3 in the brain.

    PMID:
    15135228
    [PubMed - indexed for MEDLINE]

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