Neurology. 1992 Sep;42(9):1815-7.

Phenotypic expression of the myotonic dystrophy gene in monozygotic twins.

Dubel JR, Armstrong RM, Perryman MB, Epstein HF, Ashizawa T.

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Department of Neurology, Baylor College of Medicine, Houston, TX 77030.

Abstract

Phenotypic expression of the myotonic dystrophy (DM) gene is highly variable even within the same family. To investigate the importance of genetic and nongenetic factors on phenotypic variability, we studied phenotypic expression in two DM twin sets with monozygosity confirmed by DNA polymorphism analysis. Our observations suggest that genetic factors are primarily responsible for modulating pleiotropic expression of the DM gene.

PMID:: 1513473; [PubMed - indexed for MEDLINE]

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