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J Clin Microbiol. 2004 May;42(5):2317-20.

Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolates.

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  • 1Center for the Study of Emerging and Re-emerging Pathogens and Department of Microbiology and Molecular Genetics, The University of Texas Medical School at Houston, Houston, Texas 77030, USA.


We examined 215 Enterococcus faecalis isolates and found that neither the two-component regulatory locus fsr (E. faecalis regulator) nor gelatinase production was more common in disease-associated isolates than in isolates colonizing healthy individuals (ca. 60 to 65%). The majority of gelatinase-negative isolates, including 14 endocarditis isolates (of 80 isolates tested), contained the previously described 23.9-kb deletion and lacked fsrA and fsrB. While these findings indicate that neither fsr nor gelatinase is required for E. faecalis to cause infection, this study did not address whether fsr or gelatinase affects the severity of disease, as it does in animal models.

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