Multidetector computed tomography provides robust evaluation of the hepatic parenchyma. It plays a critical role in the detection of liver metastases and the assessment of treatment response to therapy. In this article, we discuss the role of multidetector computed tomography in the detection and characterization of hepatic metastases, and the value of image processing with volume rendering and maximum-intensity projection techniques in the accurate delineation of hepatic vascular anatomy and the segmental localization of lesions. This information is critical in the diagnosis and treatment of patients with metastatic disease and is essential in surgical and nonsurgical planning.