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1: Genome Biol. 2004;5(5):R34. Epub 2004 Apr 27.Click here to read Click here to read Links

Orthologous gene-expression profiling in multi-species models: search for candidate genes.

Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG.

Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, East Monument Street, Baltimore, MD 21287, USA.

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

PMID: 15128448 [PubMed - indexed for MEDLINE]

PMCID: PMC416470