Phys Med Biol. 2004 Apr 7;49(7):1227-34.

Three-dimensional cellular-level imaging using full-field optical coherence tomography.

Dubois A, Moneron G, Grieve K, Boccara AC.

Source

Laboratoire d'Optique Physique, Ecole Supérieure de Physique et Chimie Industrielles, Centre National de la Recherche Scientifique, UPR A0005, 10 rue Vauquelin, F-75231 Paris Cedex 5, France.

Abstract

An ultrahigh-resolution full-field optical coherence tomography (OCT) system has been developed for cellular-level imaging of biological media. The system is based on a Linnik interference microscope illuminated with a tungsten halogen lamp, associated with a high-resolution CCD camera. En face tomographic images are produced in real time, with the best spatial resolution ever achieved in OCT (0.7 microm x 0.9 microm, axial x transverse). A shot-noise limited detection sensitivity of 80 dB can be reached with an acquisition time per image of 1 s. Images of animal ophthalmic biopsies and vegetal tissues are shown.

PMID:: 15128200; [PubMed - indexed for MEDLINE]

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Related citations in PubMed

Ultrahigh-resolution full-field optical coherence tomography. [Appl Opt. 2004]
Ultrahigh-resolution full-field optical coherence tomography.
Dubois A, Grieve K, Moneron G, Lecaque R, Vabre L, Boccara C. Appl Opt. 2004 May 10; 43(14):2874-83.
Stroboscopic ultrahigh-resolution full-field optical coherence tomography. [Opt Lett. 2005]
Stroboscopic ultrahigh-resolution full-field optical coherence tomography.
Moneron G, Boccara AC, Dubois A. Opt Lett. 2005 Jun 1; 30(11):1351-3.
Ocular tissue imaging using ultrahigh-resolution, full-field optical coherence tomography. [Invest Ophthalmol Vis Sci. 2004]
Ocular tissue imaging using ultrahigh-resolution, full-field optical coherence tomography.
Grieve K, Paques M, Dubois A, Sahel J, Boccara C, Le Gargasson JF. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4126-31.
Review [Methodological advancements. Ultrahigh-resolution OCT]. [Ophthalmologe. 2004]
Review [Methodological advancements. Ultrahigh-resolution OCT].
Drexler W. Ophthalmologe. 2004 Aug; 101(8):804-12.
Review [Full-field OCT]. [Med Sci (Paris). 2006]
Review [Full-field OCT].
Dubois A, Boccara C. Med Sci (Paris). 2006 Oct; 22(10):859-64.

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Cited by 8 PubMed Central articles

Improved Detection Sensitivity of Line-Scanning Optical Coherence Microscopy. [IEEE J Sel Top Quantum Electro...]
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Auksorius E, Bromberg Y, Motiejūnaitė R, Pieretti A, Liu L, Coron E, Aranda J, Goldstein AM, Bouma BE, Kazlauskas A, et al. Biomed Opt Express. 2012 Mar 1; 3(3):661-6. Epub 2012 Feb 27.
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