Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genetics. 2004 Apr;166(4):1661-72.

Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.

Author information

  • 1Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA. kaeber@u.washington.edu

Abstract

The SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.

PMID:
15126388
[PubMed - indexed for MEDLINE]
PMCID:
PMC1470832
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk