Semin Cell Dev Biol. 2004 Jun;15(3):309-23.

The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction.

Source

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK.

Abstract

It is well established that stimulation of G-protein coupled receptors (GPCRs) can activate signalling from receptor tyrosine kinases by a process termed transactivation. Indeed, in recent years, it has become apparent that transactivation is a general phenomenon that has been demonstrated for many unrelated GPCRs and receptor tyrosine kinases. In this case the GPCR/G-protein participation is up-stream of the receptor tyrosine kinase. Substantial research has addressed these findings but meanwhile another mechanism of cross talk has been slowly emerging. For over a decade, a growing body of evidence has demonstrated that numerous growth factors use G-proteins and attendant signalling molecules such as beta-arrestins that participate down-stream of the receptor tyrosine kinase to signal to effectors, such as p42/p44 MAPK. This review highlights this novel mechanism of cross talk between receptor tyrosine kinases and GPCRs, which is distinct from growth factor receptor transactivation by GPCRs.

PMID:: 15125894; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction. [Methods Enzymol. 2004]
Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction.
Pyne NJ, Waters C, Moughal NA, Sambi B, Connell M, Pyne S. Methods Enzymol. 2004; 390:451-75.
Review Signal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: lessons from bradykinin signaling. [Curr Med Chem. 2000]
Review Signal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: lessons from bradykinin signaling.
Liebmann C, Böhmer FD. Curr Med Chem. 2000 Sep; 7(9):911-43.
Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. [Biochemistry. 2005]
Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth.
Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA Jr, Chan TO, Penn RB. Biochemistry. 2005 Nov 8; 44(44):14595-605.
Review Receptor tyrosine kinase-GPCR signal complexes. [Biochem Soc Trans. 2003]
Review Receptor tyrosine kinase-GPCR signal complexes.
Pyne NJ, Waters C, Moughal NA, Sambi BS, Pyne S. Biochem Soc Trans. 2003 Dec; 31(Pt 6):1220-5.
Review Mitogenic signaling pathways induced by G protein-coupled receptors. [J Cell Physiol. 2007]
Review Mitogenic signaling pathways induced by G protein-coupled receptors.
Rozengurt E. J Cell Physiol. 2007 Dec; 213(3):589-602.

See reviews... See all...

Cited by 9 PubMed Central articles

Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells. [Cell Signal. 2011]
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells.
Edelstein J, Hao T, Cao Q, Morales L, Rockwell P. Cell Signal. 2011 Jan; 23(1):239-48. Epub 2010 Sep 16.
A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. [Mol Biol Cell. 2010]
A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.
Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, et al. Mol Biol Cell. 2010 Jul 1; 21(13):2338-54. Epub 2010 May 12.
Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. [Mol Biol Cell. 2010]
Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation.
Shi GX, Jin L, Andres DA. Mol Biol Cell. 2010 May 1; 21(9):1597-608. Epub 2010 Mar 10.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of G-protein coupled receptors and associated proteins in receptor tyro...
The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction.
Semin Cell Dev Biol. 2004 Jun ;15(3):309-23.

PubMed
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinas...
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Science. 1999 Jan 29 ;283(5402):655-61.

PubMed
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by ph...
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
J Biol Chem. 1997 Dec 5 ;272(49):31051-7.

PubMed
Structure of the signal recognition particle interacting with the elongation-arr...
Structure of the signal recognition particle interacting with the elongation-arrested ribosome.
Nature. 2004 Feb 26 ;427(6977):808-14.

PubMed
Long-term treatment of postmenopausal osteoporosis with strontium ranelate: resu...
Long-term treatment of postmenopausal osteoporosis with strontium ranelate: results at 8 years.
Bone. 2009 Dec ;45(6):1059-64. Epub 2009 Aug 11 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: