J Am Chem Soc. 2004 May 12;126(18):5688-9.

N1...N3 hydrogen bonds of A:U base pairs of RNA are stronger than those of A:T base pairs of DNA.

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Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.

Abstract

Trans-hydrogen-bond deuterium isotope effects of Watson-Crick A:U and A:T base pairs of 10 homologous RNA and DNA duplexes are compared. The isotope effect at 13C2 of adenosine residues due to deuterium/protium substitution at the imino H3 site, 2hDelta13C2, is larger in RNA than in DNA. The virtually consistent larger isotope effects in RNA suggest that the N1...N3 hydrogen bonds of A:U base pairs of RNA are stronger than those of the A:T base pairs of DNA.

PMID:: 15125660; [PubMed - indexed for MEDLINE]

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