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Genome Res. 2004 May;14(5):988-95.

GeneWise and Genomewise.

Author information

  • 1The European Bioinformatics Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. birney@ebi.ac.uk

Abstract

We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.

PMID:
15123596
[PubMed - indexed for MEDLINE]
PMCID:
PMC479130
Free PMC Article

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