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    Head Neck. 2004 May;26(5):408-17.

    Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases.

    Rosso P, Cortesina G, Sanvito F, Donadini A, Di Benedetto B, Biffo S, Marchisio PC.

    Source

    Otolaryngological Clinic II, University of Torino, 10126 Torino, Italy.

    Abstract

    BACKGROUND:

    p27(BBP) is a regulator of ribosome assembly and an essential nuclear and cytoplasmic component of eukaryotes.

    METHODS:

    We investigated the immunochemical distribution of p27(BBP) in head and neck carcinomas, in the associated normal mucosa, and in regional lymph nodes.

    RESULTS:

    p27(BBP) is detectable in mucosal cells but is overexpressed in carcinomas, highly concentrated in large polymorphous nucleoli, and even larger and more evident in lymph node metastatic foci. Western blotting confirms increased p27(BBP) in carcinomas versus normal mucosa and also in metastatic versus normal lymph nodes. The overexpression of p27(BBP) corresponds to mRNA upregulation in carcinomas. Unexpectedly, a 52-kDa band specifically reacting with antibodies to p27(BBP) was observed in several carcinomas.

    CONCLUSIONS:

    p27(BBP) alterations are common events in the transition to malignancy and are probably involved in squamous carcinoma progression. Immune reagents raised to p27(BBP) may provide additional diagnostic tools for surgical pathology of tumor boundaries and lymph nodes. The 52-kDa band may represent an abnormal form of p27(BBP) expressed by transformed airway epithelia.

    Copyright 2004 Wiley Periodicals, Inc. Head Neck 26: 408-417, 2004

    PMID:
    15122657
    [PubMed - indexed for MEDLINE]

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