Lancet. 2004 May 1;363(9419):1439-41.

Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.

Le Blanc K, Rasmusson I, Sundberg B, Götherström C, Hassan M, Uzunel M, Ringdén O.

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Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. Katarina.Leblanc@medhs.ki.se

Abstract

Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

Comment in

Immunomodulatory functions of mesenchymal stem cells. [Lancet. 2004]
Immunomodulatory functions of mesenchymal stem cells.Frank MH, Sayegh MH. Lancet. 2004 May 1; 363(9419):1411-2.
Mesenchymal stem cells for acute graft-versus-host disease. [Lancet. 2008]
Mesenchymal stem cells for acute graft-versus-host disease.Miura Y, Kami M, Tsubokura M, Takei N, Komatsu T. Lancet. 2008 Aug 30; 372(9640):715-6; author reply 716.

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