Int J Dermatol. 1992 Jun;31(6):443-5.

Ofloxacin versus cephalexin for treating skin and soft tissue infections.

Lipsky BA, Yarbrough DR 3rd, Walker FB 4th, Powers RD, Morman MR.

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General Internal Medicine Clinic, Seattle VA Medical Center (111M), WA 98108.

Abstract

Patients with acute localized skin or soft tissue infections were randomized to receive either ofloxacin (300 mg orally, b.i.d.) or cephalexin (500 mg orally, b.i.d.). Among 401 enrolled patients, 382 were evaluable for safety and 148 for microbiologic response. Microbiologic cure occurred in 93.4% of ofloxacin-treated patients and in 94.0% of those treated with cephalexin. Clinical cure or improvement, respectively, was found in 85.2% and 11.1% of patients treated with ofloxacin, and 83.6% and 14.9% of patients receiving cephalexin. Adverse effects (primarily associated with the gastrointestinal tract and central nervous system) were considered to be drug-related in 7.9% of those receiving ofloxacin and 4.8% of those receiving cephalexin. Thus, ofloxacin is as effective and well tolerated as cephalexin and a good alternate antibiotic for treating skin and skin structure infections caused by a variety of pathogens.

PMID:: 1512105; [PubMed - indexed for MEDLINE]

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Ofloxacin versus cephalexin in the treatment of skin, skin structure, and soft-tissue infections in adults. [Clin Ther. 1991]
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Cited by 1 PubMed Central article

Once-daily oral gatifloxacin versus oral levofloxacin in treatment of uncomplicated skin and soft tissue infections: double-blind, multicenter, randomized study. [Antimicrob Agents Chemother. 2...]
Once-daily oral gatifloxacin versus oral levofloxacin in treatment of uncomplicated skin and soft tissue infections: double-blind, multicenter, randomized study.
Tarshis GA, Miskin BM, Jones TM, Champlin J, Wingert KJ, Breen JD, Brown MJ. Antimicrob Agents Chemother. 2001 Aug; 45(8):2358-62.

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