Bioinformatics. 2004 Nov 1;20(16):2851-2. Epub 2004 Apr 29.

Gene-Ontology-based clustering of gene expression data.

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Department of Molecular Developmental Biology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany. boris.adryan@mpi-bpc.mpg.de

Abstract

The expected correlation between genetic co-regulation and affiliation to a common biological process is not necessarily the case when numerical cluster algorithms are applied to gene expression data. GO-Cluster uses the tree structure of the Gene Ontology database as a framework for numerical clustering, and thus allowing a simple visualization of gene expression data at various levels of the ontology tree. AVAILABILITY: The 32-bit Windows application is freely available at http://www.mpibpc.mpg.de/go-cluster/

PMID:: 15117760; [PubMed - indexed for MEDLINE]

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