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Trends Pharmacol Sci. 2004 Apr;25(4):175-7.

Diacylglycerol's affair with protein kinase C turns 25.

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  • 1Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, USA.


This year marks the 25-year anniversary of the discovery by Nishizuka and co-workers that diacylglycerol activates the ubiquitous signal transducer protein kinase C. This discovery placed the lipid second messenger-protein kinase C signaling pathway center stage alongside the cAMP-protein kinase A pathway, which was already established as a fundamental mechanism for transducing extracellular signals.

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