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    Ann Pharmacother. 2004 Jun;38(6):986-8. Epub 2004 Apr 27.

    Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid.

    Mogenet I, Raetz-Dillon S, Canonge JM, Archambaud M, Bonnet E.

    Pharmacy Department, Rangueil University Hospital, Toulouse, France. imogenet@chu-clermontferrand@fr

    OBJECTIVE: To report a case of Staphylococcus epidermidis infection of a hip prosthesis successfully treated with oral linezolid. CASE SUMMARY: A 46-year-old woman developed methicillin-resistant S. epidermidis (MRSE) infection of her prosthetic hip. She received oral linezolid 600 mg twice daily for one month; after that time, the biological inflammatory markers returned to normal. DISCUSSION: One of the most serious complications of arthroplasty is joint prosthesis infection. It is mainly caused by gram-positive bacteria, in particular those of the genus staphylococcus. The increasing prevalence of gram-positive cocci that are resistant to antimicrobial agents has complicated the treatment of serious infections. CONCLUSIONS: Oral linezolid appears to be an effective and well-tolerated treatment option for hip prosthesis infections due to MRSE.

    PMID: 15113981 [PubMed - indexed for MEDLINE]

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