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Behav Neurosci. 2004 Apr;118(2):389-94.

Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.

Author information

  • 1Department of Physiology, Ponce School of Medicine, Ponce, PR 00732-7004.

Abstract

The authors recently showed that extinction of auditory fear conditioning leads to potentiation of tone-evoked activity of neurons in the infralimbic (IL) subregion of the medial prefrontal cortex, suggesting that IL inhibits fear after extinction (M. R. Milad, & G. J. Quirk, 2002). In support of this finding, pairing conditioned tones with brief (300-ms) electrical stimulation of IL reduces conditioned freezing. The present study showed that IL stimulation inhibits freezing if given 0.1 s after tone onset (the latency of tone-evoked responses) but has no effect if given either 1 s before or 1 s after tone onset. This suggests that IL gates the response of downstream structures such as the amygdala to fear stimuli.

PMID:
15113265
[PubMed - indexed for MEDLINE]
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