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J Am Chem Soc. 2004 May 5;126(17):5370-1.

Conductance titration of single-peptide molecules.

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  • 1Center for Solid State Electronics, Arizona State University, Tempe, Arizona 85287, USA.


We have measured the conductance of single peptides covalently bonded to two Au electrodes via S-Au bonds by repeatedly forming a large number of molecular junctions. The conductance decreases exponentially with the peptide length, with a decay constant of beta = 0.9 +/- 0.1 A-1, suggesting that tunneling is the mechanism of electron transport in the peptides. The conductance of the peptides is sensitive to the solution pH, due to the protonation/deprotonation of the amine and carboxyl groups of the peptides, which provides titration measurements based on single-molecule conductance.

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