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1: Chem Biol. 2004 Jan;11(1):7-8.Click here to read Links
Comment on:
Chem Biol. 2004 Jan;11(1):57-67.

Breaking up is easy to do (if you're a DNA enzyme that cleaves RNA).

Silverman SK.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana 61801, USA.

In this issue of Chemistry & Biology, Cruz et al. use in vitro selection to select deoxyribozymes that collectively cleave almost any RNA dinucleotide junction. More remarkable is the finding that the new enzymes are related to the 8-17 deoxyribozyme that cleaves AG dinucleotide junctions.

PMID: 15112985 [PubMed - indexed for MEDLINE]