Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bull World Health Organ. 2004 Mar;82(3):213-8. Epub 2004 Apr 16.

Tobacco smoking and oral clefts: a meta-analysis.

Author information

  • 1Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Scotland.

Abstract

OBJECTIVE:

To examine the association between maternal smoking and non-syndromic orofacial clefts in infants.

METHODS:

A meta-analysis of the association between maternal smoking during pregnancy was carried out using data from 24 case-control and cohort studies.

FINDINGS:

Consistent, moderate and statistically significant associations were found between maternal smoking and cleft lip, with or without cleft palate (relative risk 1.34, 95% confidence interval 1.25-1.44) and between maternal smoking and cleft palate (relative risk 1.22, 95% confidence interval 1.10-1.35). There was evidence of a modest dose-response effect for cleft lip with or without cleft palate.

CONCLUSION:

The evidence of an association between maternal tobacco smoking and orofacial clefts is strong enough to justify its use in anti-smoking campaigns.

PMID:
15112010
[PubMed - indexed for MEDLINE]
PMCID:
PMC2585921
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Scientific Electronic Library Online Icon for PubMed Central
    Loading ...
    Write to the Help Desk