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    Cytokine Growth Factor Rev. 2004 Apr-Jun;15(2-3):157-68.

    Cytokines in Mycoplasma pneumoniae infections.

    Source

    Department of Pathology and Pathophysiology, and Proteomics Research Center, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310031, China

    Abstract

    Mycoplasma pneumoniae (M. pneumoniae) is one of the smallest free-living bacteria known. Along with other unique characteristics of this genus, it lacks the typical peptidoglycan cell wall of most eubacteria. Best known for causing tracheobronchitis and atypical pneumonia in humans, this pathogen also causes a number of extrapulmonary syndromes such as meningitis/encephalitis and arthritis. Recent studies also suggest that infection may be associated with chronic conditions such as asthma. Although the mechanisms of M. pneumoniae pathogenesis remain to be elucidated, one important component of M. pneumoniae infections is the induction of proinflammatory and other cytokines in both acute and chronic conditions. In this review, we survey the induction of cytokines by M. pneumoniae in different model systems, and we discuss the possible role of induced cytokines in M. pneumoniae pathogenesis.

    PMID:
    15110799
    [PubMed - indexed for MEDLINE]

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