Microbes Infect. 2004 Apr;6(5):494-500.

Resistance of HIV-infected cells to cytotoxic T lymphocytes.

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Department of Internal Medicine, The University of Michigan, Ann Arbor 48109, USA. klcollin@umich.edu

Abstract

Although cytotoxic T lymphocytes (CTLs) are important for controlling HIV, CTLs are not effective at eradicating HIV infection. Recent studies have revealed a combination of factors that together make HIV-infected cells resistant to CTLs and make anti-HIV CTLs ineffective. These factors likely contribute to prolonged survival of infected target cells, which in turn increases the probability of antigenic variation and immune escape.

PMID:: 15109965; [PubMed - indexed for MEDLINE]

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