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    Bioorg Med Chem Lett. 2004 May 17;14(10):2427-31.

    Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.

    Source

    Faculty of Engineering, Kyushu Institute of Technology, Kitakyushu 808-8550, Japan. nishino@life.kyutech.ac.jp

    Abstract

    Cyclic tetrapeptide retrohydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors and evaluated the inhibitory activity and found that they have potential as anticancer drugs.

    PMID:
    15109626
    [PubMed - indexed for MEDLINE]

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