Int J Biochem Cell Biol. 2004 Jul;36(7):1141-6.

Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms.

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Skin Cancer Research Program, Department of Pathology and the Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA. mdennin@lumc.edu

Abstract

Squamous cells form the outermost layers of the epidermis, and though they are readily discarded from the tissue, they serve a vital water barrier function while in the stratum corneum. The generation of cornified or squamous keratinocytes involves a complex, multi-step differentiation process that insures the proper physical and immunological barrier functions of the epidermis are maintained. The regulation of keratinocyte terminal differentiation is influenced by a large number of signaling pathways. This article will review some recent findings regarding the roles of the protein kinase C (PKC) family in normal keratinocyte differentiation, as well as their involvement in skin diseases, especially skin cancer.

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