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Am J Med Genet A. 2004 May 15;127A(1):81-5.

Cutaneous T-cell lymphoma in a 21-year-old male with Wolf-Hirschhorn syndrome.

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  • 1Department of Pediatrics, William Beaumont Hospital, 3601 West Thirteen Mile Road, Suite 4700, Royal Oak, MI 48073, USA.


We describe a case of cutaneous T-cell lymphoma occurring in a 21-year-old male with Wolf-Hirschhorn syndrome (WHS) due to a chromosome 4p16.3 deletion. This is the first documented case report of malignancy occurring in an adult with WHS. We also review the literature regarding patients with WHS and the joint occurrence of malignancy and discuss genetic changes involving chromosome 4 which may have contributed to the genesis of our patient's lymphoma.

Copyright 2003 Wiley-Liss, Inc.

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