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J Lipid Res. 2004 Sep;45(9):1583-93. Epub 2004 Apr 21.

Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I.

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  • Department of Medicine, University of California San Diego, La Jolla, CA 92093-0682, USA. dsteinberg@ucsd.edu

Abstract

This is the first of a series of reviews of the controversy that swirled around the "lipid hypothesis" of atherosclerosis for so many years. Today, in the era of the statins, there is no longer any doubt about the value of decreasing blood cholesterol levels. In fact, "the lower the better" is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future. The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future.

Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.

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PMID:
15102877
[PubMed - indexed for MEDLINE]
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