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Agents Actions. 1992 Jan;35(1-2):50-6.

Acute pulmonary toxicity of inhaled beta-1,3-glucan and endotoxin.

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  • 1Department of Environmental Medicine, University of Gothenburg, Sweden.


The number of inflammatory cells was studied in lung walls and airways after inhalation of endotoxin or beta-1,3-glucan. In the water unsoluble form, beta-1,3-glucan caused a delayed response in terms of a decrease in macrophages and lymphocytes in the lung wall, 1 to 7 days after exposure but no invasion of neutrophils into the airways. When solubilized in 0.02 N NaOH, the cell response was the same as that observed after exposure to endotoxin.

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