Nutr Rev. 2004 Mar;62(3):96-104.

Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review.

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Department of Physical Medicine and Rehabilitation, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.

Abstract

It has been hypothesized that idiopathic carpal tunnel syndrome (CTS) is a manifestation of vitamin B6 deficiency. Some claim that B6 supplementation can alleviate symptoms. Others argue that pain relief occurs because of vitamin B6's anti-nociceptive properties or because B6 supplementation addresses an unrecognized peripheral neuropathy. Few studies on CTS and B6 employed electrodiagnostic techniques in diagnosis, and few showed a correlation between symptoms and improved electrodiagnostic parameters with supplementation. Other studies failed to measure or estimate B6 levels. Nevertheless, it appears reasonable to recommend vitamin B6 supplementation to people with CTS. Some patients will improve symptomatically with low risks of toxicity in recommended doses.

PMID:: 15098856; [PubMed - indexed for MEDLINE]

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Pyridoxine

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Related citations in PubMed

Review Vitamin B6 (pyridoxine) therapy for carpal tunnel syndrome. [Hand Clin. 1996]
Review Vitamin B6 (pyridoxine) therapy for carpal tunnel syndrome.
Jacobson MD, Plancher KD, Kleinman WB. Hand Clin. 1996 May; 12(2):253-7.
Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. [Am J Clin Nutr. 1979]
Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome.
Ellis J, Folkers K, Watanabe T, Kaji M, Saji S, Caldwell JW, Temple CA, Wood FS. Am J Clin Nutr. 1979 Oct; 32(10):2040-6.
Carpal tunnel syndrome and vitamin B6. [Klin Wochenschr. 1989]
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Laso Guzmán FJ, González-Buitrago JM, de Arriba F, Mateos F, Moyano JC, López-Alburquerque T. Klin Wochenschr. 1989 Jan 4; 67(1):38-41.
Brief communication: effect of pharmacologic doses of vitamin B6 on carpal tunnel syndrome, electroencephalographic results, and pain. [J Am Coll Nutr. 1993]
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Bernstein AL, Dinesen JS. J Am Coll Nutr. 1993 Feb; 12(1):73-6.
Review Pharmacotherapy of carpal tunnel syndrome. [Expert Opin Pharmacother. 2003]
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Cited by 1 PubMed Central article

Review Carpal tunnel syndrome and vitamin B6. [Can Fam Physician. 2007]
Review Carpal tunnel syndrome and vitamin B6.
Ryan-Harshman M, Aldoori W. Can Fam Physician. 2007 Jul; 53(7):1161-2.

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