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Nat Med. 2004 May;10(5):484-6. Epub 2004 Apr 18.

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.

Author information

  • 1Cancer Biology and Genetics Program, and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

PMID:
15098029
[PubMed - indexed for MEDLINE]
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