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Nat Neurosci. 2004 May;7(5):491-2. Epub 2004 Apr 18.

Towing of sensory axons by their migrating target cells in vivo.

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  • 1Max Planck Institut für Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tuebingen, Germany.


Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.

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