Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Am Acad Dermatol. 2004 May;50(5):777-9.

Pathogenesis of androgenetic alopecia.

Author information

  • 1Section of Dermatology, Department of Endocrinological and Metabolic Sciences, University of Genoa, Genoa, Italy. rebdermo@unige.it


Although it is universally accepted that dihydrotestosterone causes baldness, how it does so is not well understood. I propose that 3 mechanisms are at work: miniaturization by a dihydrotestosterone-induced acceleration of the mitotic rate of the matrix that leaves less and less time for differentiation; an increased telogen shedding as a result of the shortening of the hair cycles that increases the telogen number per unit of time; and the increased number and duration of the lag phase or kenogen. That this last mechanism is related to dihydrotestosterone is unclear.

Comment in

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk