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1: J Am Acad Dermatol. 2004 May;50(5):777-9.Click here to read Links
Comment in:
J Am Acad Dermatol. 2005 Feb;52(2):374-5.

Pathogenesis of androgenetic alopecia.

Rebora A.

Section of Dermatology, Department of Endocrinological and Metabolic Sciences, University of Genoa, Genoa, Italy. rebdermo@unige.it

Although it is universally accepted that dihydrotestosterone causes baldness, how it does so is not well understood. I propose that 3 mechanisms are at work: miniaturization by a dihydrotestosterone-induced acceleration of the mitotic rate of the matrix that leaves less and less time for differentiation; an increased telogen shedding as a result of the shortening of the hair cycles that increases the telogen number per unit of time; and the increased number and duration of the lag phase or kenogen. That this last mechanism is related to dihydrotestosterone is unclear.

PMID: 15097964 [PubMed - indexed for MEDLINE]

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